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 Research
 
The research in our lab focuses on the principles and mechanisms of decision making in rodents. We are interested in the computational principles, neural correlates as well as the neural circuit dynamics supporting decision processes. In addition to electrophysiological recordings of large populations of neurons, we are adapting optical and genetic tools for use in behaving animals in order to manipulate specific neural cell types and pathways.
 

Current projects:

Neural representation and behavioral impact of decision uncertainty

Previously we showed that many neurons in orbitofrontal cortex (OFC) signal decision confidence. We are pursuing these initial observations by trying to establish that confidence-related neural activity in the OFC is causally related to confidence judgments. In addition, we are studying how uncertainty may be used behaviorally to modulate learning and exploration.

Temporal coordination of activity between brain regions

How do brain areas dynamically coordinate their activity to produce coherent and seamless coordination of actions? We are exploring the hypothesis that oscillatory activity in the theta frequency range (4-12Hz) can serve as the basis for inter-areal communication. Our initial explorations focus on the coordination of sniffing, whisking and hippocampal oscillations.

Opto-genetic tools in behaving rodents

We are adapting optical-genetic techniques for use in freely behaving mice to enable us to reliably activate and simultaneously record from a genetically specified class of neurons. Our long-term goal is to causally link the activity of specific neural types and pathways to behavioral decisions.

Role of cholinergic basal forebrain in learning and attention


Cold Spring Harbor Laboratory